We are so pleased that this month's chat guest will be Dr. Ronny Drapkin (@ronny_drapkin). Dr. Drapkin is the Franklin Payne Associate Professor of Pathology in Obstetrics and Gynecology at the University of Pennsylvania's Perelman School of Medicine. His research focuses on understanding the genetic, molecular and physiological factors that drive the development of gynecologic cancers.
April's chat will focus on the origination of high grade serous ovarian cancer. In 2017, Dr. Drapkin and colleagues published the paper High grade serous ovarian carcinomas originate in the fallopian tube in Nature communications. You may read the article here. An understanding of the precursors of ovarian cancer and gene alterations can lead to the development of an early detection test.
We will use the following topic questions to guide our discussion:
We will use the following topic questions to guide our discussion:
T1: What makes HGSOC different from other sub-types in terms of the tumor itself, how it spreads, how it is treated, and its prognosis?T2: When did research start pointing to the fallopian tubes as the origin site of HGSOC?T3: What characteristics did you study when you examined fallopian tube lesions versus lesions of the ovary? How are BRCA mutations involved?T4a: Are HGSOC cancer cells found in the fallopian tube different than those found in/on the ovary? How do they differ from Fallopian Tube Cancer cells?T4b: Patients/survivors - Have your pathology reports shown cancer cells in your fallopian tubes?T5: As we look to the future:How will knowledge of where a majority of ovarian cancers originate impact women at increased risk?How might this research help in the development of an early detection test?What is the impact for women diagnosed with ovarian cancer?
In this video, Dr. Drapkin discusses how this research is giving high-risk women better choices:
We hope you can join us on Wednesday, April 10, 2019 at 9:00pm ET (8pm CT, 6pm PT) to learn more about this important research topic.
Dee
#gyncsm co-moderator
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