Thursday, July 23, 2015

Genetic Testing and Ovarian Cancer

Genetic Testing and Ovarian Cancer originally appeared as a blog post on the National Society of Genetics Counselors (NSGC) website on Mar 23, 2015. It was written by Leigha Ann Senter-Jamieson, MS, LGC. Thank you  NSGC and Liegha Senter-Jamieson for allowing us to share this important information with the #gyncsm community.  



DNA Double Helix
As a genetic counselor specializing in ovarian cancer, I was heartened to learn about a recently approved chemotherapy treatment for women with a type of inherited ovarian cancer. In December, the US. Food and Drug Administration granted accelerated approval of Lynparza (also known as olaparib) for women whose ovarian cancer is caused by an inherited mutation in the BRCA1 or BRCA2 gene. Currently, this treatment is only for women whose cancer has failed to respond to three other types of chemotherapy.

Precision Medicine
This is an exciting example of how our understanding of the role of genetics in cancer is advancing the field of precision medicine, and bringing hope to women with ovarian cancer or anyone with a cancer that’s resistant to many of our standard treatments.

If you or a close relative has ovarian cancer, you may want to learn more about this treatment option, and consider genetic testing and genetic counseling. Genetic counseling both before and after the test is key.

What Genetic Testing Can Tell You
Genetic testing for ovarian cancer can provide information beyond whether a specific type of chemotherapy might be effective. It can tell you whether your particular type of cancer is hereditary and whether your close relatives, men included, may be at increased risk for developing ovarian cancer or other cancers, and whether they should consider being tested. Data suggest that up to 15 percent of women with ovarian cancer have a BRCA1 or BRCA2 mutation. These genes are associated with a 50 percent to 80 percent lifetime risk of breast cancer and a 20 to 40 percent lifetime risk of ovarian cancer in women, as well as an increased risk for breast cancer in men. These cancer risks are much higher than the risks faced by the general population. Because of this, women with the BRCA gene mutations are advised to begin cancer screenings at an earlier age and have them more often. Some women also consider having surgery to remove their ovaries or their breasts, which significantly lowers their risk of developing cancer. Since men may also inherit a BRCA1 or BRCA2 mutation, genetic testing is important for male relatives to consider as well since their screening would be adjusted if they were found to have the mutation.
Genetic counseling both before and after [genetic testing] is key.

While BRCA1 and BRCA2 mutations are the most common causes of hereditary ovarian cancer, there are less common genetic causes of the disease. In fact, many women with ovarian cancer now choose to have more extensive genetic testing utilizing what is often referred to as multi-gene panel testing. These tests analyze many genes at once and often include the BRCA genes. Multi-gene panels usually include other well-known genes that are less commonly associated with ovarian cancer risk. For some of the genes included in these tests, there are no published guidelines regarding cancer screening so it’s up to your cancer genetics care team to design a screening plan based on the available data.

The Role of Genetic Counseling
The information provided by genetic testing can be extremely useful, but it can also be overwhelming. A genetic counselor can help you decide which genetic test is right for you, guide you through the test results and what they mean for you and your family, and help you consider your options for screening, prevention or treatment.  
If you’d like to speak with a genetic counselor, you can locate one in your area using NSGC’s “Find a Genetic Counselor” tool.


Leigha Senter-Jamieson, MS, LGC is a member of the National Society of Genetic Counselors 2015 Board of Directors and is associate professor in the Division of Human Genetics in the Department of Internal Medicine at The Ohio State University



Dee
Co-moderator #gyncsm

Wednesday, July 8, 2015

Dealing With Anxiety July 8, 2015 Chat

One of the questions on our October of 2014 survey asked about chat topic ideas for the coming year. Over 90% of the survey takers rated "Dealing With Anxiety" as important or moderately important topic. Tonight's chat proved the importance of the topic among the members of our community. We had 53 participants, 536 tweets in the hour and over 1.2 million impressions. We were happy the Association of Oncology Social Workers (@oncosocialwork) was able to join us.

The questions that guided our discussion and a few of the responses:
T1: What instances seem to cause the greatest anxiety among cancer patients and survivors? What are your triggers?



T2: Have you spoken to your healthcare provider about what causes your anxiety? Did it help? Do providers bring up and provide info?



T3: What are tips and resources to relieve anxiety? What have you found to be helpful in dealing with anxious feelings?




T4: In the bigger picture, what are ways that we can change the healthcare system itself so that patients experience less anxiety?



If you missed the chat you may read the transcript here and the analytics here. Please scroll down for list of resources mentioned during the chat. And you may continue the conversation on the Smart Patients platform at https://www.smartpatients.com/gyncsm

We hope you will join us next month on August 12, 2015 to discuss Dealing with Short and Long Term Side Effects. Please remember to tweet using the #gyncsm hashtag to share information with our community.


Dee
#gyncsm co-moderator and co-founder

RESOURCES

Definitions of Anxiety and Depression
http://www.anxietycoach.com/anxiety-and-depression.html

NCI  @theNCI - Adjustment to Cancer:Anxiety and Depression
http://www.cancer.gov/about-cancer/coping/feelings/anxiety-distress-pdq

Cancer.Net @cancerdotnet
http://www.cancer.net/coping-and-emotions/managing-emotions/anxiety

Cancer Care
http://www.cancercare.org/tagged/anxiety?gclid=CJ3A86XkzMYCFQmKaQod4GUPuA

Cure Today: Scanxiety With Lynch Syndrome
http://www.curetoday.com/community/georgia-hurst/2015/04/scanxiety-with-lynch-syndrome

ASCO One in Three People with Cancer has Anxiety or other Mental Health Challenges
http://www.asco.org/press-center/one-three-people-cancer-has-anxiety-or-other-mental-health-challenges

JCO : Screening, Assessment and Care of Anxiety and Depressive Symptoms...
http://jco.ascopubs.org/content/32/15/1605.full

Gyn Onc : Depression, Anxiety, and Quality of Life in Patients with Epithelial Ovarian Cancer http://t.co/bdOGIIIcGU

British Journal of Health Psychology: Social support, anxiety and depression after chemo for ovarian cancer: A prospective study http://t.co/YmGwnUKQLx

JCO : Evidence-Based Treatment of Anxiety in Patients With Cancer 
http://t.co/99PebxIS8v

CancerConnect.com   Psychosocial Needs of Survivors of Gynecologic Cancers Must Be Addressed http://t.co/4lMSF9w5AZ

Medivizor 15 tips for Coping with Scanxiety
http://medivizor.com/blog/2014/06/03/15-tips-cope-scanxiety/

13 Things People With Anxiety Are Tired of Hearing, And What You Can Say Instead
http://themighty.com/2015/07/13-things-people-with-anxiety-are-tired-of-hearing-and-what-you-can-say-instead/?utm_campaign=site_twit&utm_source=twitter&utm_medium=social

Health Journeys - Meditation resources
http://www.healthjourneys.com/Store/Anxiety-Relief/29

NOCC - Living with OC
http://www.ovarian.org/coping.php

Reiki: Helping to Relieve the Anxiety of Cancer Patients
http://t.co/o9wP7XvfPw

Society of Gynecologic Oncology @SGO_org
https://www.sgo.org/

NY Times:
Anxiety Lingers Long After Cancer
http://well.blogs.nytimes.com/2013/07/12/anxiety-lingers-long-after-cancer/?_r=1
Lost in Transition
http://well.blogs.nytimes.com/2015/03/16/lost-in-transition-after-cancer/

@nannyangel

Nanny Angel Network provides free, professional relief childcare to mothers with cancer & their families.

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Friday, July 3, 2015

July 8th chat - Dealing with Anxiety

This month on Wednesday July 8, 2015 the #gyncsm community will be discussing "Dealing with Anxiety".

Anxiety is defined as "a feeling of worry, nervousness or unease". The NCI states that anxiety disorders include excessive anxiety, worry, fear, and/or dread.

We hope that you will join us in sharing what aspects of cancer cause you anxiety and what you have learned that helps you cope with anxiety.

Below are the questions that will guide our discussion.

T1: What instances seem to cause the greatest anxiety among cancer patients and survivors? What are your triggers?

T2: Have you spoken to your healthcare provider about what causes your anxiety? Did it help? Do providers bring up and provide info?

T3: What are tips and resources to relieve anxiety? What have you found to be helpful in dealing with anxious feelings?

T4: In the bigger picture, what are ways that we can change the healthcare system itself so that patients experience less anxiety?


To prepare for the chat, here is a topic overview from the National Cancer Institute: "Adjustment to Cancer: Anxiety and Distress".  

We look forward to having you join us at 9pm (EST) on the 8th.

Dee
#gyncsm co-moderator